Cisplatin review

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August undefined, 2024

WebSep 15, 2024 · SIDE EFFECTS. Nephrotoxicity - Dose-related and cumulative renal insufficiency is the major dose-limiting toxicity of cis-platin.Renal toxicity has been noted … WebJun 3, 2024 · In the present review, we investigate the role of epithelial–mesenchymal transition (EMT) in the emergence of cisplatin (CP) resistance. CP is a key member of platinum compounds with excellent anti-tumor activity against different cancers such as breast cancer, prostate cancer, bladder cancer, lung cancer, brain tumors, and so on …

Recognizing cisplatin as a potential radiation recall ... - Springer

WebNature Reviews Cancer - Platinum chemotherapy agents remain among the most widely used anticancer drugs, but there is still room to maximize their efficacy. This Review … WebDec 1, 2024 · Methods. In this open-label, randomized, phase III study, newly diagnosed patients with advanced NSCLC were initially randomized (R1, 1:1) to receive first-line treatment with cisplatin 75 mg/m 2 plus docetaxel 75 mg/m 2 (DC75) or 60 mg/m 2 (DC60) for up to 4 cycles. Patients without progression were further randomized (R2, 1:2) to best … high temperature flat magnets

Pathophysiology of cisplatin-induced acute kidney injury

WebFeb 1, 2024 · drowsiness. feeling of fullness in the ears. fever or chills. increased thirst. loss of appetite. loss of balance. loss of hearing. lower back or side pain. nausea or vomiting. WebThis review will focus on cisplatin, one of the most commonly used chemotherapeutic drugs to date. Its primary action is by the interaction with DNA in order to for DNA … WebCisplatin and other platinum derivatives are the most widely used chemotherapeutic agents to treat solid tumors including ovarian, head and neck, and testicular germ cell tumors. A known complication of cisplatin administration is acute kidney injury (AKI). The nephrotoxic effect of cisplatin is cum … high temperature filter factory

Review on Pharmacology of Cisplatin: Clinical Use, …

Cisplatin Uses, Side Effects & Warnings - Drugs.com

WebOct 5, 2014 · Cisplatin, cisplatinum, or cis-diamminedichloroplatinum (II), is a well-known chemotherapeutic drug. It has been used for treatment of numerous human cancers including bladder, head and neck, lung, ovarian, and testicular cancers. It is effective against various types of cancers, including carcinoma … WebJan 13, 2024 · Cisplatin molecules within the intracellular space are redox-available and perpetuate the proliferation of ROS/RNS, increase the abundance of some redox enzymes while depleting others, and increase calcium [Ca. 2+] influx. Anyone or more of such perturbations may lead to nuclear or mitochondrial DNA damage. how many die from depressionWebMost voted positive review. 39 People found this comment helpful . Stage three cancer at base of tongue. Now 45 months in remission. Received 62 radiation and 21 hrs of … high temperature flat washer

"WebJul 12, 2007 · Cisplatin is a very effective cancer drug and has had a major clinical impact, particularly for patients with testicular or ovarian cancers. But, it is notoriously toxic to the kidneys... " - Cisplatin review

Cisplatin review

(PDF) Cisplatin nephrotoxicity. A review - ResearchGate

WebApr 24, 2024 · Cisplatin is a platinum-based alkylating compound that reacts with DNA to form interstrand cross-links and intrastrand bifunctional N-7 DNA adducts at d (GpG) and d (ApG) 3. Cisplatin is renally excreted and can accumulate in the renal proximal tubules, leading to nephrotoxicity. WebCisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. Therefore, identifying novel biomarkers to improve the diagnosis and treatment of NSCLC is important.

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WebOct 23, 2003 · Cisplatin is a neutral inorganic, square planar complex that reacts with DNA to induce its characteristic biological effects, which culminate in either repair of the DNA damage and cell survival... WebA systematic review was performed to evaluate clinical studies that have examined hydration and supplementation strategies to prevent cisplatin-induced nephrotoxicity. …

WebCisplatin Nephrotoxicity: A Review XIN YAO, MD; KESSARIN PANICHPISAL, MD; NEIL KURTZMAN, MD; KENNETH NUGENT, MD ABSTRACT: Background: Cisplatin is a major antineo-plastic drug for the treatment of solid tumors, but it has dose-dependent renal toxicity. Methods: We reviewed clinical and experimental literature on cisplatin nephro- WebOct 13, 2024 · In this Review, we provide an overview of the mechanisms that underlie cisplatin-induced AKI and CKD and discuss the therapeutic implications of potential …

WebJul 22, 2024 · Cisplatin-induced kidney toxicity is reviewed here. The use of cisplatin in patients with pre-existing kidney dysfunction and the kidney effects of the platinum … WebMay 24, 2006 · Background Cisplatin is a well-known nephrotoxic antineoplastic drug. Chronic hypokalemic metabolic alkalosis with hypomagnesemia and hypocalciuria is one of the rare complications associated with its use. Case presentation A 42- year-old woman presented with a 20 year-history of hypokalemic metabolic alkalosis with …

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WebApr 5, 2024 · Abstract. Cisplatin is a platinum containing drug first approved as an antineoplastic agent in 1978. It remains an important and effective therapy in many forms of cancer today. Cisplatin mediates its … high temperature flint and walling pumpsWebFeb 16, 2024 · Generic name: cisplatin [ sis-PLA-tin ] Brand names: Platinol, Platinol-AQ, Platinol (Restricted Access) Dosage forms: intravenous powder for injection (50 mg), … high temperature flexible pipeWebThis review covered the hallmarks of inflammation common and distinct between different CITs, the role of innate immune components in development of CITs, as well as current … how many die from cancer each yearWebJul 1, 2024 · Abstract Cisplatin or (SP-4-2)-diamminedichloridoplatinum (II) is one of the most potential and widely used drugs for the treatment of various solid cancers such as … how many die from covid vaccinationWebSep 21, 2016 · Cisplatin produced superior response rates and survival in head and neck cancers. There are no published randomized phase III studies of bladder, cervical, endometrial, and esophageal cancers. CONCLUSION: Carboplatin does not possess equivalent activity to cisplatin in all platinum-sensitive tumors. how many die from domestic violenceWebThe purpose of the review is to consolidate the reported risk of cardiotoxicity in patients treated with cisplatin based chemotherapy. Cisplatin can induce direct myocardial toxicity leading to atrial fibrillation whereas the potential of myocardial toxicity is amplified when the drug is administered in combination with other cardiotoxic agents. high temperature fireplace adhesiveWebJun 24, 2011 · Interstrand crosslinks (ICLs) are a type of DNA damage that is induced by various chemotherapeutics, such as cisplatin. This Review discusses how these lesions are repaired through multiple ... how many die from flu each year