WebThe CYP19A1Cre targets Cre recombinase selectively to ovarian granulosa cells for deleting floxed genes in these cells. Hemizygous: There is not phenotype of these mice. … WebNov 13, 2024 · A granulosa cell (GC) specific Adar depleted mouse model [ Adar flox/flox: Cyp19a1- Cre/+ (gc Adar KO)] was used to evaluate the role of ADAR1 during the …
Epigenetic modifications during sex change repress ... - PubMed
WebDec 22, 2024 · Mitochondrial unfolded protein response (UPRmt) is a highly conserved mechanism, which is activated upon cellular or metabolic stress and aims to help cells maintain homeostasis. CLPP (caseinolytic peptidase P) plays a crucial factor for UPRmt; it promotes the degradation of unfolded mitochondrial proteins. WebDec 1, 2016 · In Cyp19a1-Cre transgenic mice, Cre driven by a −180-bp promoter region between exon 1 and exon 2 of human CYP19a1 is selectively expressed in round cells in … china towel radiator brackets supplier
Epigenetic modifications during sex change repress
WebJan 6, 2016 · One novel gene that we identified in the Cebpa/bfl/fl;Cyp19a1-Cre mutant ovary microarray is growth arrest specific-1 ( Gas1) [ 10 ]. The Gas1 gene also has potential C/EBP binding sites [ 18, 19] and is markedly reduced in granulosa cells of the Cebpa/bfl/fl;Cyp19a1-Cre mutant mice [ 10 ]. WebThe Cyp19a1-Cre transgenic line was generated by BAC (bacterial artificial chromosome) recombination (Yao et al., 2024). A Lox-STOP-Lox-tdTomato reporter line with a LoxP-flanked STOP was used to express tdTomato in Cre + cells (Ai9, The Jackson Laboratory; Madisen et al., 2010). Homozygous Cyp19a1-Cre mice were crossed with homozygous … WebThe Cyp19a1-Cre transgenic line was generated by BAC (bacterial artificial chromosome) recombination (Yao et al., 2024); its expression pattern faithfully recapitulates endogenous aromatase expression (Yao et al., 2024) and displays no known behavioral deficits in either heterozygous or homozygous animals. china towel bar holders