WebCocrystal formation between nicotinamide and five fenamic acid derivative drugs (flufenamic acid, niflumic acid, tolfenamic acid, mefenamic acid and meclofenamic acid) was investigated using solution-based and solid-state preparation methods. It was anticipated that the well-known acid–aromatic nitrogen heterosynthon would provide a … WebEffects of three polymers, polyethylene glycol (PEG), polyvinylpyrrolidone (PVP), and copolymer of vinylpyrrolidone/vinyl acetate (PVP-VA), on the dissolution behavior of the …

Cocrystals of Fenamic Acids with Nicotinamide

WebInsight into Flufenamic Acid Cocrystal Dissolution in the Presence of a Polymer in Solution: from Single Crystal to Powder Dissolution Minshan Guo,† Ke Wang,† Ning Qiao,‡ László Fábián,§ Ghazala Sadiq,⊥ and Mingzhong Li *,† † School of Pharmacy, De Montfort University, Leicester, LE1 9BH, U.K. ‡ College of Materials Science and Engineering, … WebCocrystallization is a technique for modifying the physicochemical and pharmacokinetic properties of an active pharmaceutical ingredient (API) embodying the concept of supramolecular synthon. Most of the examples cited in the literature are of cocrystals formed between an API and a coformer chosen from the generally recognized as safe (GRAS ... d and s shuffle

Multicomponent Pharmaceutical Cocrystals: A Novel Approach for …

WebDec 30, 2024 · In this work we form a basis for knowledge-based synthesis and formulation of model pharmaceutical cocrystal (flufenamic acid, FFA: nicotinamide, NA; 1:1) via matrix-assisted cocrystallisation ... WebFeb 3, 2024 · The molecular interactions between the surfaces of cocrystals [i.e., flufenamic acid and theophylline (FFA-TP), flufenamic acid and nicotinamide (FFA … d and s thompson contractors