Witryna13 kwi 2024 · Download Citation Paraneoplastic autoimmune hypophysitis: a novel form of paraneoplastic endocrine syndrome Paraneoplastic syndromes are defined by symptoms or signs resulting from damage to ... Monoclonal antibodies against PD-(L)1 and CTLA-4 have revolutionized cancer treatment and are FDA-approved for numerous oncologic indications for both unresectable disease and as adjuvant therapy for resected disease. Although immune checkpoint inhibitors (ICI) are clinically active in a proportion … Zobacz więcej Patients treated with ICI in Yale Cancer Center’s Melanoma and Renal Cell Carcinoma (RCC) Programs were prospectively … Zobacz więcej Availability of the dataset can be discussed on a case-by-case basis with the corresponding author. Requests to access the datasets should be directed to [email protected]. Zobacz więcej Here we report on our single institution experience with hypophysitis in patients treated with ICI, the majority of whom had melanoma. The … Zobacz więcej
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WitrynaPrimary hypophysitis is a rare inflammatory, autoimmune disorder of the pituitary gland where the immune cells (predominantly leukocytes) infiltrate the gland. ... The same … Witryna7 lut 2024 · The use of immune checkpoint inhibitors (ICIs) as a mono- or adjuvant oncologic treatment is rapidly expanding to most fields of cancer. Alongside their efficacy, ICIs carry the risk of immune-related adverse events (irAEs) arising from misguided immune-mediated response to normal tissues. In the cardiovascular system, the … signs of using marijuana
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WitrynaThyroid abnormalities and hypophysitis are the two most common endocrine irAEs, although primary adrenal insufficiency and type 1 diabetes mellitus have also been … Witryna9 mar 2024 · Immune-mediated hypophysitis or hypopituitarism occurred in patients receiving IMFINZI (see section 4.8). Patients should be monitored for clinical signs and symptoms of hypophysitis or hypopituitarism. For symptomatic hypophysitis or hypopituitarism, patients should be managed as recommended in section 4.2. ... Witryna7 kwi 2024 · Immune-mediated adverse reactions, which may be severe or fatal, can occur in any organ system or tissue, can affect more than one body system … signs of verbal abuse from husband