Lithoplocamia lithistoides
Web11 dec. 2024 · At difference with the above cited phase II anticancer drugs, plocabulin (PM060184) is not an ADC but it is a Lithoplocamia lithistoides sponge-derived polyketide which acts as a very potent antimitotic agent, binding to a specific β-tubulin site with possible activity on tumors resistant to other tubulin inhibitors . Web1 apr. 2014 · PM060184 belongs to a new family of tubulin-binding agents originally isolated from the marine sponge Lithoplocamia lithistoides. This compound is currently produced by total synthesis and is under evaluation in clinical …
Lithoplocamia lithistoides
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WebIsolation of PM050489 (1): The frozen specimen of Lithoplocamia lithistoides(61 g), collected by hand using SCUBA diving in Madagascar (S 17º 06.071' / E 49º 51.385') at a depth ranging between 6 and 20 m, was diced and extracted with H2O (3 x 200 mL) and then with a mixture of MeOH:CH2Cl2 (50:50, 3 x 200 mL) at 23 ºC. Web17 mrt. 2024 · Plocabulin (PM060184/PM184, PharmaMar) is a compound of marine origin derived from the Madagascan sponge Lithoplocamia lithistoides. Plocabulin belongs to a family of tubulin-binding agents that inhibits tubulin polymerization by binding to the dimer’s end, with one of the highest known affinities among tubulin-binding agents.
WebLithoplocamia lithistoides Dendy, 1922 AphiaID 167995 (urn:lsid:marinespecies.org:taxname:167995) Classification Biota Animalia (Kingdom) … WebGenus: Lithoplocamia Species (6): L. atlantica – L. dolichosclera – L. indica – L. lithistoides – L. minor – L. tuberculata. Name . Lithoplocamia Dendy, 1922 References …
Web1 nov. 2024 · Plocabulin, a marine natural polyketide isolated from the sponge Lithoplocamia lithistoides, is a novel and potent microtubule-destabilizing agent. … Webde Voogd, N.J.; Alvarez, B.; Boury-Esnault, N.; Carballo, J.L.; Cárdenas, P.; Díaz, M.-C.; Dohrmann, M.; Downey, R.; Hajdu, E.; Hooper, J.N.A.; Kelly, M.; Klautau ...
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WebGlobal Biodiversity Information Facility. Free and Open Access to Biodiversity Data. grass fed organic meat near meWebOriginally isolated from the Madagascan marine sponge Lithoplocamia lithistoides, plocabulin is now obtained by total synthesis [3]. Plocabulin binds tubulin with high a nity, reducing its polymerization and depolymerization to a similar extent and thereby inhibiting microtubule dynamicity (Figure1) [4–6]. chittenden reservoir vt ice fishingWebLithoplocamia lithistoides. Lithoplocamia lithistoides adalah spesies spons yang tergolong dalam kelas Demospongiae. Spesies ini juga merupakan bagian dari genus Lithoplocamia dan famili Raspailiidae. Nama ilmiah spesies ini pertama kali diterbitkan pada tahun 1922 oleh Dendy. Seperti spons pada umumnya, spesies ini memiliki tubuh … chittenden reservoir vt fishingWeb1 nov. 2024 · Plocabulin, a marine natural polyketide isolated from the sponge Lithoplocamia lithistoides, is a novel and potent microtubule-destabilizing agent. … grass-fed organic meatWeb10 jul. 2013 · Paclitaxel is arguably the most well-known and commercially successful mitosis inhibitor; intriguingly, these new compounds isolated from the Madagascan sponge Lithoplocamia lithistoides show a distinct biochemical mechanism of … grass fed organic meat ukWebLithoplocamia lithistoides adalah spesies spons yang tergolong dalam kelas Demospongiae. Spesies ini juga merupakan bagian dari genus Lithoplocamia dan famili … grass fed organic meat deliveryWebLithoplocamia lithistoides (Q2418850) From Wikidata. Jump to navigation Jump to search. species of sponge. edit. Language Label Description Also known as; English: … grass fed organic hamburger